Service
CHO Cell Culture Process Development
Our aim is to provide all customers with biopharmaceutics-related services and products that enable a smooth transition between early R&D efforts to clinical trials and eventual commercial production. This transition relies on scaled-up and sustainable production processes. JSBio’s CHO cell culture process development platform provides our clients with a series of services including cell line development, development and optimization of cell culture medium formulation, process development and scale-up of the culture process, as well as many others tailored to suit your project needs. Our platform can assist you in:
Enhancing productivity
Improving product quality
Reducing the risk of contamination
Reducing cost
Accelerating the time required to market your product
CHO Cell Culture Process Development: Flexible Choice to Support Every Step
I.Cell Line Devlopment
Fexiable construction carrier: Cells
Gene Sequence provided: JSBio provides one-stop cell line construction service
Plasmid Provided: JSBio provides cell line construction and single clone selection
Transfected cells provided: JSBio provides single clone selection and stability validation
II.CHO Cell Culture Media Formulation Development and Process Optimization
The CHO cell culture medium formulation development process uses a high-throughput screening system and a DOE experimental design approach to optimize the process from TPP tubes and shaker bottles to 2L bioreactors.
Fed-batch culture process
Optimization of basal and feed medium formulations
Optimization of addition of Feed media strategy
Optimization of process parameters
Perfusion Process（Continuous Perfusion and Concentrated Fed-batch）
Optimization of Media formulations
Optimization of Perfusion Process parameters
III.CHO Cell Culture Process Scale-up
Our facility has a variety of bioreactor sizes for production of your biologics on the scale of 2 L, 15 L, 50 L, 300 L, 1200 L, as well as specialized scales to accommodate client needs. We possess a variety of bioreactor brands that are disposable and non-disposable. Our range of equipment provides a number of services to our clients, such as: scale-up, process characterization, process optimization, and final process verification.
IV.Clinical Filing Related Document Support
Media production batch records
cGMP documentation of the media development and optimization process
cGMP documentation of process development and optimization process
Pilot production batch records that meet regulatory filing requirements teansfer and other related documentation
Process development and trchnology transfer reports
Continuous technical support
Downstream process development
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0931-7706502
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